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一、震颤麻痹震颤麻痹是Tames Parkinson 于1817年提出的,是出中脑黑质神经细胞的变性脱落所致。症状以手足震颤、肌肉僵硬和动作缓慢为主。1.流行病学本病在神经变性疾病中发生率较高,日本每10万人中即有50名患者。英、美、瑞典等白人更多,患者约为日本的2～3.5倍。2.病因黑质的神经细胞能制造并储存多巴胺,然后将多巴胺循神经纤维上行,送到大脑半球(?)部的纹状体的神经细胞。一旦黑质的神经细胞受到损害,则纹状体的多巴胺缺乏而出现震颤麻痹的神经症状。然而造成黑质神经障碍的机制仍不明。
A paralysis paralysis Parkinsonism paralysis was proposed by Tames Parkinson in 1817 and was caused by the degeneration of the substantia nigra neurons in the midbrain. Symptoms of hand-foot tremor, muscle stiffness and slow movements dominated. 1. Epidemiology The disease in the high incidence of neurodegenerative diseases in Japan, that is, 50 patients per 100,000 people. More white people such as Britain, the United States and Sweden, the patients are about 2 to 3.5 times of Japan. 2. Causes The substantia nigra neurons produce and store dopamine, which then travels up the nerve fibers to the neurons in the striatum of the cerebral hemispheres (?). Once the substantia nigra neurons are damaged, the striatum of dopamine is deficient and neurotic symptoms of paralysis appear. However, the mechanisms that cause nigral neurological disorders remain unclear.