目的　探讨人乳脂质在肠道炎症中的作用机理及抗炎症特性。　方法　予SD 大鼠人乳脂质5 周后,再用乙酸制做大鼠溃疡性结肠炎模型,观察乳脂对结肠炎粘膜的保护作用。　结果　乳脂组能显著降低乙酸导致的大鼠结肠粘膜损伤指数和粘膜髓过氧化物酶( MPO) ,乳脂组的大鼠结肠组织血栓素( TXB2) 含量,明显低于对照组;乳脂能提高大鼠组织超氧化岐化酶(SOD) 活性及VE 含量,减少对机体有害的过氧化脂质(LPO) 含量。　结论　乳脂质具有抗炎症、保护粘膜的作用。这也可能是母乳喂养儿较少发生肠道炎症以及坏死性小肠结肠炎的重要因素之一 Objective To investigate the mechanism and anti-inflammatory properties of human milk lipids in intestinal inflammation. Methods After 5 weeks of human milk lipids of SD rats, ulcerative colitis model was induced by acetic acid, and the protective effect of milk fat on colonic mucosa was observed. Results Cream group can significantly reduce acetic acid-induced colonic mucosal injury index and mucosal myeloperoxidase (MPO), milk fat group of rat colon tissue thromboxane (TXB 2) content was significantly lower than the control group; Improve the activity of superoxide dismutase (SOD) and the content of VE in rat tissues, and reduce the content of peroxidation lipid (LPO) which is harmful to the body. Conclusion Milk lipids have anti-inflammatory and mucosal protective effects. This may also be one of the more important factors in the less inflamed and necrotizing enterocolitis in breastfeeding infants