当今世界上的药物数以万计,新药还在不断涌现,无论作为医生,还是药师都难以了解掌握,当前严重存在着不合理使用和滥用药物的现象,致使药源性疾病与药疗事故不断增加。近年来,许多研究结果显示,药物血中浓度与疗效的相关性远较药物剂量与疗效来得密切。为避免药物在体内积聚而造成中毒,尤其对有效药物浓度狭窄,治疗指数小的药物,剂量调解更为重要。目前在美、 There are tens of thousands of drugs in the world today. New drugs are still emerging. They are hard to understand and understand as doctors and pharmacists. At present, there are serious phenomena of unreasonable use and drug abuse, leading to drug-related diseases and medical accidents increase. In recent years, many studies have shown that the drug concentration and efficacy of the correlation is much closer than the dose and efficacy of the drug. To avoid accumulation of drugs in the body caused by poisoning, especially for the effective drug concentration is narrow, the therapeutic index of small drugs, dose mediation is even more important. Currently in the United States,