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对象为53±8(4～66)岁的 14(男 7、女7)例轻～中度原发性高血压患者,服安慰剂30天后舒张压>12.7kPa,各例均无心脏、神经或肾脏受累,也无下肢闭塞性动脉硬化或糖尿病。试验按双盲、交叉和安慰剂对照的方式进行。服30天安慰剂后,随机分为2组。前4周,A组先服bisoprolol(10mg,qd),B组先服安慰剂。后4周,交叉服药。在分组前,第四周末和第八周末(服药后5小时)进行测定。采用二维脉冲多普勒超声仪测定颈总动脉和肱动脉的血液动力学参数。该超声仪有二个特点:(1)多普勒信号的二维记录,2个探头互成60°角,入射超声和血管轴
Subjects were 14 (7 males and 7 females) with mild to moderate essential hypertension of 53 ± 8 (4 to 66) years old. Diastolic blood pressure was> 12.7 kPa after 30 days of placebo. There were no heart and nerve in each case Or kidney involvement, nor obstructive arteriosclerosis or diabetes. The trials were conducted in a double-blind, crossover and placebo-controlled manner. After 30 days of placebo, they were randomly divided into two groups. In the first 4 weeks, group A received bisoprolol (10 mg, qd) and group B received placebo. After 4 weeks, cross medication. The determination was made before, during the fourth week and the end of the eighth week (5 hours after taking the medicine). The hemodynamic parameters of common carotid artery and brachial artery were measured by two-dimensional pulsed Doppler ultrasound. The system has two distinct features: (1) two-dimensional recording of the Doppler signal, two probes angled at 60 ° into each other, incident ultrasound and a vascular axis