目的 :测定格列吡嗪片的药动学及相对生物利用度。方法 :12名健康男性志愿者单剂量随机交叉口服5mg格列吡嗪片后 ,经高效液相色谱法测定血浆药物浓度。结果 :口服重庆制药七厂或海南金晓制药有限公司生产的格列吡嗪片后血药浓度达峰时间分别为 (2 86±0 56)h和 (2 92±0 7)h ,峰浓度分别为 (267 26±64 35)ng/ml和 (260 14±43 89)ng/ml,药 -时曲线下面积分别为(1721 53±505 17)ng/(h·ml)和 (1714 00±266 29)ng/(h·ml)。结论 :两种片剂具有生物等效性 Objective: To determine the pharmacokinetics and relative bioavailability of glipizide tablets. Methods: Twelve healthy male volunteers were randomized to receive oral administration of 5 mg glipizide tablets. The plasma drug concentration was determined by high performance liquid chromatography (HPLC). Results: The peak plasma concentrations of gatifloxacin produced by Chongqing Pharmaceutical Factory No. 7 or Hainan Jinxiao Pharmaceutical Co., Ltd. were (2 86 ± 0 56) h and (2 92 ± 0 7) h, respectively. Peak concentrations (267 26 ± 64 35) ng / ml and (260 14 ± 43 89) ng / ml, and the areas under the drug-time curve were (1721 53 ± 505 17) ng / (h · ml) and ± 266 29) ng / (h · ml). Conclusion: The two tablets are bioequivalent