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先天性膈疝（CDH）继发新生儿持续性肺动脉高压（PPHN）是新生儿高病死率的重要原因之一，是导致CDH患儿生后出现呼吸、循环衰竭的重要因素。CDH继发PPHN的病情危重，治疗困难，治疗预后差，故针对阻止CDH病理进程的产前干预已成为研究热点，尤其是关于阻断PPHN形成过程的病因治疗。鉴于PPHN的病因尚不明确，治疗效果差，该文以国内外相关研究为基础，综述CDH-PPHN的发病机制与治疗研究进展，以期为相关研究与临床治疗提供参考。“,”Persistent pulmonary hypertension of the newborn (PPHN) secondary to congenital diaphragmatic hernia (CDH) is one of the main reasons for high mortality of the newborn and a factor that leads to respiratory and circulatory failure in newborns with CDH. PPHN secondary to CDH is severe and dififcult to treat, with poor prognosis. Therefore, prenatal intervention aims for preventing the pathological process of CDH, especially the etiological treatment for impeding the development of PPHN, has become a research focus. Given unknown causes and poor outcomes of PPHN, this article summarizes the research advances in pathogenesis and treatment of PPHN secondary to CDH based on related studies so as to provide a reference for relevant studies and clinical treatment.