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目的探讨IL-6、IL-8、TNF-α、C反应蛋白(CRP)参与COPD的发病机制,并将其与FEV 1% pred分别进行相关分析。方法选择新入院COPD急性发作期患者25例抽血测定上述指标水平及治疗2周后水平,并与正常人做比较。结果COPD患者急性发作期与缓解期IL-6、IL-8、TNF-α、CRP水平亦明显高于健康者(P<0.051)。且治疗前与治疗后相比,治疗前较治疗后差异均具统计学意义(P<0.05)。治疗前4项指标与FEV 1% pred分别进行相关分析,发现均与FEV 1% pred呈现负相关,差异有统计学意义(P<0.05)。结论IL-6、IL-8、TNF-α、CRP共同参与了COPD气道炎症反应,均与FEV 1% pred呈现负相关,并且在炎症瀑布效应中起重要作用。
Objective To investigate the pathogenesis of IL-6, IL-8, TNF-α and C-reactive protein (CRP) involved in COPD and to analyze the association with FEV 1% pred respectively. Methods Twenty-five patients with acute exacerbation of COPD were enrolled in this study. Blood samples were taken for determination of the above indexes and the levels after 2 weeks of treatment, and compared with normal subjects. Results The levels of IL-6, IL-8, TNF-α and CRP in acute exacerbation and remission of COPD patients were significantly higher than those in healthy controls (P <0.05 1). Before treatment and after treatment, compared with before treatment, the differences were statistically significant (P <0.05). Correlation analysis showed that there was a negative correlation between FEV 1% pred and FEV 1% pred before treatment, respectively, with a statistically significant difference (P <0.05). Conclusions IL-6, IL-8, TNF-α and CRP are involved in airway inflammation in COPD. Both of them are negatively correlated with FEV 1% pred and play an important role in inflammatory cascade.