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目的:观察生脉二陈汤治疗放射性肺损伤临床疗效及对肿瘤坏死因子(TNF-α)表达水平的影响。方法:将70例肺癌放射治疗后肺损伤患者随机分为2组。治疗组口服生脉二陈汤,连续3周。对照组予吸氧,祛痰,激素及抗生素治疗。观察临床疗效及治疗前后测定血浆TNF-α水平。结果:有效率治疗组82.9%,对照组54.3%,2组比较,差异有显著性意义(P<0.05)。治疗组治疗前后血浆TNF-α比较,差异有显著性意义(P<0.05);对照组治疗前后血浆TNF-α比较,差异有显著性意义(P>0.05)。结论:生脉二陈汤能有效治疗放射性肺损伤,并可抑制放射治疗后血浆TNF-α表达,可用于放射性肺损伤的治疗。
Objective: To observe the clinical effects of Shengmai Erchen Decoction on radiation-induced lung injury and its effect on the expression of tumor necrosis factor (TNF-α). Methods: Seventy patients with lung injury after radiotherapy of lung cancer were randomly divided into two groups. Treatment group oral Shengmai two Chen Tang, for 3 weeks. Control group to oxygen, expectorant, hormones and antibiotics. To observe the clinical efficacy and determination of plasma TNF-α levels before and after treatment. Results: The effective treatment group 82.9%, control group 54.3%, two groups, the difference was significant (P <0.05). There was significant difference in plasma TNF-α between the two groups before and after treatment (P <0.05). There was significant difference in plasma TNF-α between the two groups before and after treatment (P> 0.05). Conclusion: Shengmai Erchen Decoction can effectively treat radiation-induced lung injury and inhibit the expression of TNF-α in plasma after radiation therapy. It can be used in the treatment of radiation-induced lung injury.