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目的确立枫蓼肠胃康滴丸最佳成型工艺。方法以丸的外观、丸重差异系数、溶散时限等为评价指标,对基质之间及药物与基质之间配比、药液温度、滴距、滴速及冷凝液温度对滴丸成型的影响进行考察。结果以PEG-4000为基质,药物:基质=1∶3.2,药液温度为80℃,滴距为3 cm,滴速为每分钟40滴,冷凝液上部温度42℃,下部温度12℃时是丸的最佳成型工艺。结论成型工艺合理可行,适合大生产。
Objective To establish the best forming process of Fengliao Weigang Kang drop pills. Methods The appearance, weight difference coefficient of pills and dissolution time limit were used as evaluation indexes to evaluate the effects of matrix, drug and matrix, liquid temperature, drip distance, drip rate and condensate temperature Impact of inspection. Results PEG-4000 was used as matrix. Drug: matrix = 1: 3.2, liquid temperature was 80 ℃, dripping distance was 3 cm, drip rate was 40 drops per minute, condensate upper temperature was 42 ℃, lower temperature was 12 ℃ Pill the best molding process. Conclusion Molding process is reasonable and feasible, suitable for large-scale production.