【摘 要】
：
MicroRNAs(miRNAs)are recognized as an essential component of the RNA family,exerting multiple and intricate biological functions,particularly in the process of tumorigenesis,proliferation,and metastatic progression.MiRNAs are altered in gastric cancer(GC)
【机 构】
：
Department of Genetics and Stanley S.Scott Cancer Center,Louisiana State University Health Sciences
论文部分内容阅读
MicroRNAs(miRNAs)are recognized as an essential component of the RNA family,exerting multiple and intricate biological functions,particularly in the process of tumorigenesis,proliferation,and metastatic progression.MiRNAs are altered in gastric cancer(GC),showing activity as both tumor suppressors and oncogenes,although their true roles have not been fully understood.This review will focus upon the recent advances of miRNA studies related to the regulatory mechanisms of gastric tumor cell proliferation,apoptosis,and cell cycle.We hope to provide an in-depth insight into the mechanistic role of miRNAs in GC development and progression.In particular,we summarize the latest studies relevant to miRNAs\'impact upon the epithelial-mesenchymal transition,tumor microenvironment,and chemoresistance in GC cells.We expect to elucidate the molecular mechanisms involving miRNAs for better understanding the etiology of GC,and facilitating the development of new treatment regimens for the treatment of GC.
其他文献
Acute myeloid leukaemia (AML) is the most common form of acute leukaemia in adults,with increasing incidence with age and a generally poor prognosis.Almost 20％ of AML patients express mutant isocitrate dehydrogenase 2 (mIDH2),which leads to the accumulati
Traditional Chinese medicine (TCM) has been an indispensable source of drugs for curing various human diseases.However,the inherent chemical diversity and complexity of TCM restricted the safety and efficacy of its usage.Over the past few decades,the comb
The dose-related adverse effects of MDM2-P53 inhibitors have caused significant concern in the development of clinical safe anticancer agents.Herein we report an unprecedented homo-PROTAC strategy for more effective disruption of MDM2-P53 interaction.The
Leading by cytotoxicity against HepG2 cells,bioactivity-guided fractionation of the EtOAc fraction from Artemisia atrovirens led to the isolation of 18 new guaianolide dimers,artematrolides A--R and lavandiolides A,B,C,H,and J.Eight compounds (1,4,10,12,1
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has become one major threat to human population health.The RNA-dependent RNA polymerase (RdRp) presents an ideal target of antivirals,whereas nucleoside analogs inhibitor is hindered by the proo
As a serine hydrolase,monoacylglycerol lipase (MAGL) is principally responsible for the metabolism of 2-arachidonoylglycerol (2-AG) in the central nervous system (CNS),leading to the forma-tion of arachidonic acid (AA).Dysfunction of MAGL has been associa
In this study,self-discriminating hybrid nanocrystals was utilized to explore the biological fate of quercetin hybrid nanocrystals(QT-HNCs)with diameter around 280 nm(QT-HNCs-280)and 550 nm(QT-HNCs-550)following oral and intravenous administration and the
Cardiovascular and metabolic diseases are the leading causes of death and disability worldwide and impose a tremendous socioeconomic burden on individuals as well as the healthcare system.Fibronectin type Ⅲ domain-containing 5 (FNDC5) is a widely distribu
Ferroptosis is a type ofcell death accompanied by iron-dependent lipid peroxidation,thus stimu-lating ferroptosis may be a potential strategy for treating gastric cancer,therapeutic agents against which are urgently required.Jiyuan oridonin A (JDA) is a n
Transcellular permeation enhancers are known to increase the intestinal permeability of en-alaprilat,a 349 Da peptide,but not hexarelin (887 Da).The primary aim of this paper was to investigate if paracellular permeability enhancers affected the intestina