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用定量手指甲襞毛细血管显微镜对25例I型糖尿病患者和27例正常人(对照)进行测量,最后的6个病人和7例健康者做手指甲襞活组织检查。体内毛细血管襻宽度作为毛细血管襻变形参数的结果表明,在糖尿病患者其数值明显高于正常人。组织病理检查表明,糖尿病病人甲襞皮肤乳头胶原沉积明显增加,胶原的沉积与糖尿病患者的甲襞皮肤乳头毛细血管内皮细胞数量和乳头大小相关。由此认为,糖尿病性微血管病,除甲襞毛细血管变形外,胶原沉积可能是代谢紊乱和毛细血管内皮细胞增殖的一个表现。
Twenty-five patients with type I diabetes mellitus and 27 normal controls (control) were measured with quantitative fingernail capillaries, and the last six patients and seven healthy controls performed fingernails biopsies. The capillary capillaries in vivo as a result of the capillary deformation parameters showed that in patients with diabetes it was significantly higher than normal. Histopathological examination showed that the deposition of collagen in the dermis of patients with diabetic retinopathy was significantly increased, and the deposition of collagen was related to the number of papillary capillary endothelial cells and the size of the nipple in diabetic patients. Therefore, diabetic microangiopathy, in addition to formazan capillary deformation, collagen deposition may be metabolic disorders and capillary endothelial cell proliferation of a manifestation.