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多年的实验研究和临床试用表明,棉酚除有镇咳作用外,更为一颇有前途的男用节育药,但临床实践也指出,服药者可偶发单纯性低血钾或低血钾性肌无力(为简便起见,两者统称低血钾症)。离体实验表明,棉酚可使兔心和大鼠、豚鼠骨骼肌失钾。在整体动物,虽棉酚或含棉酚饲料可偶致豚鼠瘫痪,但此项瘫痪似与钾代谢无关,因其多属临死前表现,且伴有间歇性抽搐和角弓反张,同时血清钾和骨骼肌钾均无明显改变;有报
Many years of experimental research and clinical trials have shown that gossypol is a promising male fertility medicine besides its antitussive effect. However, clinical practice has also pointed out that gossypol can induce occasional simple hypokalemia or hypokalemia Muscle weakness (for simplicity, both collectively referred to as hypokalemia). In vitro experiments show that gossypol can make rabbit heart and rat, guinea pig skeletal muscle loss of potassium. In whole animals, although gossypol or gossypol feed can cause guinea pig paralysis, but this paralysis seems to have nothing to do with potassium metabolism, because it is mostly pre-mortem performance, and accompanied by intermittent convulsions and corner arch reverse, at the same time Serum potassium and skeletal muscle potassium were no significant change;