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[目的]探讨非酒精性脂肪性肝病(NAFLD)合并多囊卵巢综合征(PCOS)与单纯NAFLD患者临床特点。[方法]回顾性分析PCOS合并NAFLD的30例女性患者(观察组)和单纯NAFLD的30例女性患者(对照组)的临床资料:血脂、胰岛素抵抗(空腹胰岛素水平)、肥胖情况、肝功能水平、尿酸、脂肪肝的严重程度(肝脾CT比值),比较2组间的差异。[结果]观察组血脂异常较对照组明显,以总胆固醇升高和高密度脂蛋白下降为主;胰岛素抵抗较为显著,空腹胰岛素水平(≥15uU/ml)较对照组高;体质量指数值、腰臀围比高于对照组;转氨酶水平、尿酸升高较对照组明显。但2组脂肪肝的严重程度比较差异无统计学意义。[结论]NAFLD合并PCOS患者ALT水平较单纯NAFLD患者高,血脂异常及胰岛素抵抗更显著。
[Objective] To explore the clinical features of patients with non-alcoholic fatty liver disease (NAFLD) complicated with polycystic ovary syndrome (PCOS) and simple NAFLD. [Methods] The clinical data of 30 female patients (observation group) and 30 female patients with NAFLD (control group) were retrospectively analyzed. The levels of serum lipids, insulin resistance (fasting insulin), obesity, liver function , Uric acid, the severity of fatty liver (CT ratio of liver and spleen), the difference between the two groups was compared. [Results] The abnormalities of blood lipid in the observation group were more obvious than those in the control group, with the increase of total cholesterol and high-density lipoprotein. The insulin resistance was more obvious. The fasting insulin level (≥15uU / ml) was higher than that of the control group. The body mass index, Waist-hip ratio higher than the control group; aminotransferase levels, uric acid increased significantly than the control group. However, there was no significant difference in the severity of fatty liver between the two groups. [Conclusion] The ALT level in NAFLD patients with PCOS is higher than that in patients with NAFLD alone, and the dyslipidemia and insulin resistance are more significant.