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目的:探索河南省低中度氟暴露地区成年男性骨密度的影响因素。方法:采用整群随机抽样方法，于2017年4-5月选择河南省开封市通许县低中度氟暴露地区的成年男性村民为调查对象。通过问卷调查、体格测量获得调查对象的基本人口学资料，并收集晨尿样本。采用离子选择电极法测定尿氟含量，使用超声波骨密度仪测量骨密度（以T值表示），利用偏相关分析与多重线性回归分析骨密度的影响因素。结果:共纳入成年男性439名，年龄、身体质量指数（BMI）、尿氟含量、T值分别为（47.99 ± 8.49）岁、（25.77 ± 3.23）kg/mn 2、（1.34 ± 0.74）mg/L、- 1.79 ± 0.79。偏相关分析显示，调整年龄后T值和BMI呈正相关（n r = 0.194，n P < 0.05）。回归分析显示，年龄每增加1岁，T值减小0.015（95% n CI：- 0.024 ~-0.005，n P < 0.05）；BMI每增加1.0 kg/m n 2，T值增加0.034（95%n CI：0.009 ~ 0.059，n P < 0.05）。交互作用分析显示，T值与超重（≥24.0 kg/m n 2）、不吸烟、饮茶和尿氟的交互作用密切相关[n β（95%n CI）：0.134（0.001 ~ 0.269）、0.163（- 0.015 ~ 0.337）、0.215（- 0.006 ~ 0.436），n P均< 0.10]。n 结论:河南省低中度氟暴露地区，成年男性的骨密度随年龄增加而降低，随BMI升高而升高。此外，低中度氟暴露更易损害吸烟人群的骨密度。“,”Objective:To explore the factors affecting bone mineral density (BMD) in adult males with low-to-moderate fluoride exposure in Henan Province.Methods:Adult male villagers from low-to-moderate fluoride exposure areas in Tongxu County, Kaifeng City, Henan Province were recruited from April to May 2017 based on cluster random sampling. Questionnaire survey, physical measurements and urinary samples collection were conducted respectively. Urinary fluoride (UF) was determined by fluoride ion-selective electrode. Ultrasound bone densitometer was used to measure BMD (T-score). Partial correlation analysis and multiple linear regression were used to analyze the influence factors of BMD.Results:A total of 439 adult males were included in this study. Age, body mass index (BMI), UF content, and T-score of the participants were (47.99 ± 8.49) years, (25.77 ± 3.23) kg/mn 2, (1.34 ± 0.74) mg/L, and-1.79 ± 0.79, respectively. Partial correlation analysis showed a significantly positive correlation between BMI and T-score after age adjustment (n r = 0.194, n P < 0.05). Multiple linear regression showed that T-score decreased by 0.015 (95% n CI:-0.024 -- 0.005, n P < 0.05) for each 1-year increase in age and T-score increased by 0.034 (95% n CI: 0.009-0.059, n P < 0.05) for each 1.0 kg/m n 2 increase in BMI. Interaction analysis showed that T-score was closely related to the interaction between overweight (≥24.0 kg/mn 2), non-smoking, tea drinking and UF [n β (95%n CI): 0.134 (0.001-0.269), 0.163 (- 0.015-0.337), 0.215 (- 0.006-0.436), n P < 0.10].n Conclusions:Our findings reveal a negative correlation between age and BMD, and a positive correlation between BMI and BMD in adult males with low-to-moderate fluoride exposure in Henan Province. In addition, low-to-moderate fluoride exposure is more likely to damage the BMD of smokers.