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目的 探讨单一HGV肝炎的临床与病理特征。方法 对被逆转录多聚酶联反应法检测HGV RNA阳性的10例患者作肝组织学检查,并以丙型肝炎患者作为对照。结果 单一HGV肝炎患者具有以下临床及病理特征;①症状轻,大部分病例是在体检中被发现的,极少有肝病体征;②血清丙氨酸转氨酶(ALT)呈轻、中度升高,且反复波动;③肝组织的病 理改变较轻,肝细胞普遍有水样变性及纤维化。结论 HGV作为单一致病因子,可产生肝脏的急、慢性病变。
Objective To investigate the clinical and pathological features of single HGV hepatitis. Methods Ten patients with positive HGV RNA detected by reverse transcriptase polymerase chain reaction were used for liver histological examination. Patients with hepatitis C were used as controls. Results The patients with single HGV hepatitis had the following clinical and pathological features: ① The symptoms were mild and most cases were found in the physical examination with few signs of liver disease. ② Serum alanine aminotransferase (ALT) And repeated fluctuations; ③ pathological changes in liver lighter, hepatocyte watery degeneration and fibrosis generally. Conclusion HGV as a single virulence factor can produce acute and chronic liver disease.