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近年来随着对丙型肝炎病毒(HCV)研究的发展,人们认识到HCV感染不仅可引起在慢性病毒性肝炎中普遍可见的肝组织损害,还可诱导自身免疫现象[1],有时不易与自身免疫性肝炎(AIH)相鉴别。研究通过对AIH和丙型肝炎伴自身免疫现象者血清自身抗体水平的检测,结合临床特征、丙氨酸氨基转移酶(ALT)、胆红素、γ-球蛋白水平和影像学检查结果,评价自身抗体水平在鉴别诊断AIH与丙型肝炎伴自身免疫现象中的价值,以及自身抗体与丙型肝炎患者临床特征的相关性。
In recent years, with the development of research on hepatitis C virus (HCV), it is recognized that HCV infection can not only cause liver tissue damage which is generally visible in chronic viral hepatitis, but also induce autoimmunity [1], sometimes not easily with itself Immune hepatitis (AIH) phase identification. This study was based on the detection of serum autoantibodies in patients with AIH and hepatitis C with autoimmune phenotype, combined with clinical features, alanine aminotransferase (ALT), bilirubin, γ-globulin levels and imaging findings The value of autoantibodies in the differential diagnosis of AIH and hepatitis C with autoimmune phenomena, and the correlation between autoantibodies and clinical features of hepatitis C patients.