论文部分内容阅读
目的建立用于测定坎地沙坦西酯含量的HPLC法。方法采用DIKMA C_(18)(200 mm×4.6 mm,5μm)色谱柱;流动相:10 mmol·L~(-1)磷酸二氢钾(pH 2.5)-乙腈(35:65,V/V);流速1.2 mL·min~(-1);检测波长254 nm。结果坎地沙坦西酯质量浓度的线性范围为1~200mg·L~(-1)(r=0.999 9),平均回收率100.03%,精密度RSD<1.0%,3批样品的含量分别为100.71%、101.27%、101.81%。结论本方法操作简便、快捷,结果准确、可靠,可用于坎地沙坦西酯片的质量控制。
Objective To establish an HPLC method for the determination of candesartan cilexetil. Methods The mobile phase consisted of 10 mmol·L -1 potassium dihydrogen phosphate (pH 2.5) - acetonitrile (35:65, V / V) and the mobile phase consisted of DIKMA C 18 (200 mm × 4.6 mm, The flow rate was 1.2 mL · min ~ (-1) and the detection wavelength was 254 nm. Results The linear range of candesartan cilexetil was 1 ~ 200 mg · L ~ (-1) (r = 0.999 9), with an average recovery of 100.03% and a precision of RSD <1.0%. The contents of three batches of samples were 100.71%, 101.27%, 101.81%. Conclusion The method is simple, rapid, accurate, reliable and can be used for the quality control of candesartan cilexetillate tablets.