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目的观察环磷酰胺、阿霉素、氟尿嘧啶常规化疗与时辰化疗在乳腺癌术后治疗中的不良反应。方法对60例乳腺癌术后化疗患者随机分成治疗组(时辰化疗)和对照组(常规化疗),治疗组30例,对照组30例,两组用药剂量、治疗周期均相同,观察其不良反应。结果主要的不良反应治疗组恶心、呕吐及骨髓抑制均比对照组明显减轻,两组差异有统计学意义(P<0.05)。结论时辰化疗可减少乳腺癌术后化疗的不良反应,增强患者对化疗的耐受性,值得临床推广应用。
Objective To observe the adverse reactions of cyclophosphamide, doxorubicin and fluorouracil routine chemotherapy and hour chemotherapy in postoperative treatment of breast cancer. Methods Sixty patients with postoperative chemotherapy of breast cancer were randomly divided into treatment group (chemotherapy) and control group (conventional chemotherapy), 30 cases in the treatment group and 30 cases in the control group. The dosage and the treatment period of the two groups were the same, and their adverse reactions . Results The major adverse reactions in the treatment group were significantly lower than those in the control group in nausea, vomiting and bone marrow suppression, the difference was statistically significant (P <0.05). Conclusion Time chemotherapy can reduce postoperative chemotherapy of breast cancer adverse reactions and enhance patient tolerance to chemotherapy, it is worthy of clinical promotion and application.