目前癌基因致癌理论的重要进展之一是用正常原代细胞代替癌前细胞(NIH/3T3),来检测癌基因的转化能力;同多个癌基因的共同作用代替单个癌基因对细胞的转化,来研究自然癌变多阶段的分子基础。这些工作的初步开展,使人们对癌基因的致癌机理有了新的了解,对细胞癌变的演进过程有了新的认识,因而正受到肿瘤研究工作者的重视。 One of the important advances in oncogene carcinogenesis theory is the use of normal primary cells instead of precancerous cells (NIH/3T3) to detect the transformation ability of oncogenes; the co-action with multiple oncogenes replaces the transformation of cells by a single oncogene. To study the molecular basis of multiple stages of natural canceration. The preliminary development of these efforts has led to a new understanding of the carcinogenic mechanism of oncogenes and a new understanding of the evolution of cell carcinogenesis, and is therefore receiving attention from oncologists.