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作者在使用过全细胞百白破菌苗免疫的65名15～24月龄婴儿和56名4～6岁儿童中,使用双盲法对含百日咳毒素(PT)和丝状血凝素(FHA)的百日咳无细胞菌苗(AC-12.5与AC-25)与普通全细胞菌苗(WC-DTP)进行比较,以评价其效果。所用百日咳无细胞菌苗由法国Merieux研究所提供,每0.5ml含PT和FHA各12.5μg(AC-12.5)或25μg(AC-25)及含10Lf破伤风类毒素和30Lf白喉类毒素的氢氧化铝吸附菌苗。普通百白破全细胞菌苗由美国的Lederle研究所提供。每0.5ml含4个单位小鼠保护力百日咳抗原,5Lf破伤风类毒素,12.5Lf白喉类毒素的磷酸铝吸附菌苗。
The authors used a double-blind, double-blinded, placebo-controlled trial of pertussis toxin (PT) and filamentous hemagglutinin (FHA) in 65 children 15 to 24 months of age and 56 children 4 to 6 years of age immunized with whole- ) Of pertussis acellular bacterin (AC-12.5 and AC-25) were compared with the conventional whole cell vaccine (WC-DTP) to evaluate the effect. The B. pertussis cell-free vaccine used was supplied by Merieux Laboratories, France, containing 0.5 μg of each of 12.5 μg (AC-12.5) or 25 μg (AC-25) of PT and FHA and 25 mg of hydroxylase (AC-25) containing 10 LF tetanus toxoid and 30 LF diphtheria toxoid Aluminum adsorption bacteria vaccine. Ordinary Baibai whole cell vaccine provided by the United States Lederle Institute. Each 0.5 ml contains 4 units of mouse protective Pertussis antigens, 5Lf tetanus toxoid, 12.5Lf diphtheria toxoid aluminum phosphate adsorption vaccine.