论文部分内容阅读
自Herman氏(1956)提出衰老的自由基学说后,人们重视到自由基与人的生理衰老密切相关,许多疾病的发生、转归都与自由基参与有关。目前SOD被认为是机体内唯一的以自由基为底物的酶,对血清SOD活力以及脂质过氧化终产物——丙二醛(MDA)的观察,可以从一个侧面反映人体衰老的生理过程和疾病中脏器、组织损伤的病理过程。临床资料老年多器官衰竭患者25例(男23.女2),年龄65～80岁;健康组32例(男26,女6),年龄65～80岁,肾功能衰竭组12例(男8,女4),年龄63～75岁;冠心病组(有陈旧性心肌梗塞或稳定性心绞痛,无心衰)20例(男15,女5),年龄65～76岁。测定血清SOD活力采用免疫化学发光法,检测
Since Herman’s (1956) proposed the theory of free radical aging, people pay much attention to the fact that free radicals are closely related to the physiological aging of human beings. The occurrence and outcome of many diseases are related to the participation of free radicals. At present, SOD is considered as the only free radical-based enzyme in the body. The observation of serum SOD activity and the end product of lipid peroxidation (MDA) can reflect the physiology of human aging And disease in organs, tissue damage pathological process. Clinical data 25 elderly patients with multiple organ failure (male 23. Female 2), aged 65 to 80 years; 32 healthy subjects (male 26, female 6), aged 65 to 80 years, 12 cases of renal failure group (male 8 , Female 4), aged 63 to 75 years old; coronary heart disease group (with old myocardial infarction or stable angina, no heart failure) 20 cases (male 15, female 5), aged 65 to 76 years. Determination of serum SOD activity by immunochemical chemiluminescence, detection