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endostatin是一种新发现的高效特异的血管抑制因子,是血管周围胶原蛋白18C末端片段,在生物学活性上,主要表现为抑制内皮细胞增殖。从而抑制在体血管生成及抗动物移植肿瘤。它的发现为抗恶性实体瘤提供了一条很有希望的途径。
Endostatin is a newly discovered highly effective and specific angiogenic inhibitor, and is a C-terminal fragment of collagen 18 around the blood vessels. In biological activity, endostatin mainly inhibits the proliferation of endothelial cells. This inhibits in vivo angiogenesis and resistance to animal transplant tumors. Its discovery provides a promising way to resist malignant solid tumors.