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高催乳素(PRL)状态除可高度引起女性性周期障碍,如产褥期哺乳性无月经,也可偶尔引起男性性功能低下。高PRL血症闭经妇女的内分泌学特征有LH节律性分泌缺如,并保持对LHRH负荷的促性腺激素增量反应,干扰外源性雌激素引起的LH释放等。但高PRL状态作用于下丘脑、垂体、性腺系统达怎样水平尚不清。为了阐明高PRL血症导致的性功能障碍的机制,作者用鼠进行了体外、内实验,现将结果报道如下。一、高PRL状态与丘脑-垂体-卵巢系统功能的关系 1.高PRL血症对促性腺的激素分泌的影响: (1)PRL影响促性腺激素基础分泌:为了阐明高催乳素状态对促性腺激素分泌的影响及其作用机制,作者用鼠进行了体外实验。通过给Wistar-今道系成熟雌鼠肾被膜
In addition to high prolactin (PRL) status can cause a high degree of female sexual cycle disorders, such as suckling without menstruation puerperium, can occasionally cause male sexual dysfunction. Endocrinology in women with high PRL hyperlipidemia LH rhythmic secretion of missing, and to maintain LHRH burden of gonadotropin increased response, interference with exogenous estrogen-induced LH release. However, the role of high PRL status in the hypothalamus, pituitary, gonadal system up to what level is unclear. In order to elucidate the mechanism of sexual dysfunction caused by hyperlipidemia, the authors conducted in vitro and in vivo experiments with mice, and the results are reported below. First, the relationship between high PRL status and the function of the thalamus - pituitary - ovarian 1. High PRL hyperlipidemia on gonadal hormone secretion: (1) PRL affect gonadotropin basal secretion: In order to clarify the high prolactin state of gonadal Hormone secretion and its mechanism of action, the author conducted in vitro experiments with rats. By giving Wistar-present tract mature male rat kidney capsule