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目的探讨3.0 T MR扩散加权成像(DWI)序列评估远端胆管癌病理分化程度的价值。方法 20例远端胆管癌按病理分化程度分组,分析不同分化程度组胆管癌的DWI图像;观察病灶的信号强度并测量表观扩散系数(ADC)值。结果 20例远端胆管癌在DWI上主要呈稍高信号和高信号(95%)。不同分化程度组间胆管癌的ADC值分别为(1.684±0.166)×10-3mm2/s,(1.443±0.135)×10-3mm2/s,(1.266±0.040)×10-3mm2/s,(1.190±0.031)×10-3mm2/s.胆管癌的ADC值随分化程度的降低逐渐下降(rs=0.928,P=0.000)。各组间ADC值的差异有统计学意义(P<0.05)。结论 3.0 T MR DWI序列能够一定程度地判断远端胆管癌的病理分化程度。
Objective To investigate the value of 3.0 T MR diffusion weighted imaging (DWI) sequence in assessing the degree of pathological differentiation of distal cholangiocarcinoma. Methods Twenty cases of distal cholangiocarcinoma were divided into groups according to the degree of pathological differentiation. The DWI images of cholangiocarcinoma with different degree of differentiation were analyzed. The signal intensity of lesions and the apparent diffusion coefficient (ADC) were measured. Results Twenty cases of distal cholangiocarcinoma showed slightly higher signals and higher signals (95%) on DWI. The ADC values of cholangiocarcinoma with different degrees of differentiation were (1.684 ± 0.166) × 10-3mm2 / s, (1.443 ± 0.135) × 10-3mm2 / s, (1.266 ± 0.040) × 10-3mm2 / s, ± 0.031) × 10-3mm2 / s.The ADC value of cholangiocarcinoma decreased gradually with the degree of differentiation (rs = 0.928, P = 0.000). The difference of ADC value among the groups was statistically significant (P <0.05). Conclusion The 3.0 T MR DWI sequence can determine the degree of pathological differentiation of distal cholangiocarcinoma to some extent.