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40名无症状的HBsAg阳性母亲所生的足月健康新生儿(男性23名,女性17名)于出生后立即肌肉注射含180IU/ml抗-HBs的免疫球蛋白(HBIg),剂量为0.5ml/kg,并在出生后第1和第3个月各皮下接种1剂福尔马林灭活、氢氧化铝为佐剂的Hevac乙型肝炎疫苗.第10个月时再加强接种1剂疫苗.每剂疫苗含5μg纯化的HBsAg.所有观察对象在第1、2剂接种前及第2、3剂接种后1个月采血,用单克隆抗体ELISA法测定血清
Full-term healthy newborns (23 males and 17 females) born of 40 asymptomatic HBsAg-positive mothers were intramuscularly injected with immunoglobulin (HBIg) containing 180 IU / ml anti-HBs at a dose of 0.5 ml / kg, and 1 dose of Hevac Hepatitis B Vaccine inactivated by formalin and aluminum hydroxide adjuvant was inoculated subcutaneously on the 1st and 3rd month after birth, one dose of which was boosted on the 10th month Each dose of vaccine contains 5μg of purified HBsAg.All the subjects in the first and second inoculation before and after 2,3 doses of 1 month after vaccination blood, monoclonal antibody ELISA assay serum