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子宫内局部给酪氨酰肼１．５ｈ后，子宫胞浆雌二醇受体（ＥｃＲ）量明显下降，３ｈ下降最明显，５ｈ后这种作用基本消失。选择给药３ｈ后为最佳作用时间，观察到酪氨酰肼使子宫ＥｃＲ下降的作用是剂效关系。酪氨酰肼使妊娠ｄ１、ｄ３、ｄ５大鼠子宫ＥｃＲ含量下降。血清雌激素（Ｅ）和孕激素（Ｐ）浓度在给药前和给药３ｈ后无显著性差异。去卵巢１０ｄ大鼠，在给酪氨酰肼３ｈ后，子宫ＥｃＲ也降低。提示酪氨酰肼的这种作用是对子宫的直接作用，而不依赖卵巢内源性雌激素和孕激素。
Intrauterine to tyrosine hydrazide 1.5h, uterine cytosolic estradiol receptor (EcR) decreased significantly, 3h decreased the most obvious, 5h after the basic disappearance of this effect. Select the best time to 3h after administration, the role of tyrosine hydrazide to reduce the role of uterine EcR is dose-effect relationship. Tyrosine hydrazide in pregnancy d1, d3, d5 rats uterine EcR decreased. Serum estrogen (E) and progesterone (P) concentrations were not significantly different before and 3h after administration. Ovary 10d rats, after giving tyrosine hydrazide 3h, uterine EcR is also reduced. Tip tyrosine hydrazide this role is the direct effect on the uterus, without relying on ovarian endogenous estrogen and progesterone.