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目的：观察中分子物质（ＭＭＳ）对急性肝功不全动物发病的影响和肠道吸附剂的保护效应。方法：用１０％ Ｄ－氨基半乳糖生理盐水腹腔注射造成大鼠急性肝功不全实验模型，将肠道吸附剂混于食物中饲喂２ｄ，再腹腔注射１０％ Ｄ－氨基半乳糖作为处理组，同时设对照组。测定肝功能指标、ＭＭＳ变化，并进行肝组织电镜观察。结果：所有检测指标数值急性肝功不全组比对照组明显增加（Ｐ＜ ０．０５～０．０１），除γ－谷氨酰转肽酶（γ－ＧＴ）外，其余指标数值在处理组明显降低（Ｐ＜ ０．０５～０．０１），电镜下见到急性肝功不全组组织超微结构有改变，而处理组却有所减轻。结论：ＭＭＳ参与大鼠急性肝功不全的发病，肠道吸附剂有保护效应。因此，ＭＭＳ的变化可作为临床判断病情和估计预后的一个指标
Objective: To observe the effect of medium molecular substance (MMS) on the pathogenesis of acute hepatic insufficiency and the protective effect of intestinal adsorbent. Methods: The experimental model of acute hepatic insufficiency was induced by intraperitoneal injection of 10% D-galactosamine saline. The intestinal adsorbent was mixed with food for 2 days and then injected intraperitoneally with 10% D-galactosamine as the treatment group , At the same time set the control group. Measurement of liver function, MMS changes, and electron microscopy of liver tissue. Results: The values of all test indexes in acute hepatic failure group were significantly higher than those in control group (P <0.05 ~ 0.01). Except for γ-glutamyl transpeptidase (γ-GT) (P <0.05 ~ 0.01). The ultrastructure of acute hepatic failure group was observed by electron microscope, while the treatment group was relieved. Conclusion: MMS is involved in the pathogenesis of acute hepatic insufficiency in rats. Intestinal adsorbent has a protective effect. Therefore, MMS changes can be used as an indicator of clinical judgment and prognosis