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目的研究布地奈德雾化吸入对轻中度支气管哮喘患者Th1/Th2细胞因子平衡的影响及具体疗效。方法中轻度哮喘78例,根据治疗方法分为常规基础治疗的常规组39例和布地奈德雾化吸入的治疗组39例,比较两组治疗前后外周血变化。结果两组治疗后2个月内白细胞介素-5(IL-5)、白细胞介素-12(IL-12)及干扰素-γ(IFN-γ)水平较治疗前均明显改善,但治疗组治疗后各项指标比同期常规组改善更加明显,差异有统计学意义(P<0.05)。结论布地奈德雾化治疗中轻度哮喘,能够降低IL-5水平,提升IL-12及IFN-γ水平,从而促进和实现Th1/Th2细胞因子的平衡,疗效值得肯定。
Objective To study the effect of inhaled budesonide on the balance of Th1 / Th2 cytokines in patients with mild to moderate bronchial asthma and its curative effect. Methods 78 cases of mild asthma, according to the treatment method is divided into conventional routine treatment group 39 cases and budesonide atomization inhalation treatment group 39 cases, comparing the two groups before and after treatment of peripheral blood changes. Results The levels of interleukin-5, interleukin-12 and interferon-gamma in two groups were significantly improved after treatment After treatment, the indexes in all groups improved more obviously than the conventional group (P <0.05). Conclusions Budesonide nebulization treatment mild asthma, can reduce IL-5 levels, increase the level of IL-12 and IFN-γ, thereby promoting and achieving Th1 / Th2 cytokine balance, the effect is worthy of recognition.