注射用骨瓜提取物,其组分为多肽类骨代谢因子、甜瓜籽提取物、多种游离氨基酸以及有机钙、磷离子、无机盐及微量元素,辅料为右旋糖酐40,临床上用于风湿、类风湿性关节炎、骨关节炎、腰腿疼痛、骨折创伤修复等。不良反应发生较少,可能出现有发热或皮疹、腹部不适、头痛、四肢无力、胸闷、心悸、呼吸困难、血压下降、过敏性休克等,文献中对该药发生过敏性休克的报道较罕见。近期我院连续发生2例患者在用注射用骨瓜提取物时出现了严重的过敏性休克,经积极抢救,予以纠正,现报道如下。例1,男,77岁,有青霉素过敏史,因“右侧肺炎、右侧胸腔积液、严重骨质疏松伴骨痛、双膝骨性关节炎”入院,入院 The composition of the bone marrow extract for injection comprises the polypeptide bone metabolism factor, the melon seed extract, the plurality of free amino acids, the organic calcium, the phosphorus ions, the inorganic salts and the trace elements, the auxiliary material is dextran 40 and is used clinically for rheumatism, Rheumatoid arthritis, osteoarthritis, waist and leg pain, fracture and wound repair. Adverse reactions occurred less likely to have fever or rash, abdominal discomfort, headache, limb weakness, chest tightness, heart palpitations, dyspnea, hypotension, anaphylactic shock, the literature reports of the drug allergic shock rare. Recently, 2 cases of continuous hospital in our hospital with injection of cantaloupe extract when there was a serious anaphylactic shock, after active rescue, to be corrected, are reported below. Example 1, male, 77 years old with a history of penicillin allergy due to “right pneumonia, right pleural effusion, severe osteoporosis with bone pain, knee osteoarthritis” admission, admission