论文部分内容阅读
1 材料与方法1.1 材料 昆明小鼠45只,体重25g,雌雄兼用,随机均分为3组;盐酸异搏定注射液;20％氨基甲酸乙酯;10％和20％保苓丹混悬液。1.2 方法 本实验采用异搏定诱发心动过缓模型造型法(李仅奎,等.中药药理实验方法学,1991;388)。各组动物于实验前1周开始给药,高剂量组小鼠以20％保苓丹混悬液0.5ml/只灌胃;低剂量组以10％保苓丹混悬液0.5ml/只灌胃;对照组以同剂量蒸馏水灌胃,每天1次,连续给药1周,于末次给药后30min,以20％氨基甲
1 Materials and methods 1.1 Materials Kunming mice 45, weighing 25 g, both male and female, were randomly divided into 3 groups; hydrochloric acid verapamil injection; 20% ethyl carbamate; 10% and 20% botanol suspension . 1.2 Methods This experiment used verapamil to induce bradycardia model modeling (Li Dankui, et al., Pharmacological Experimental Methods of Traditional Chinese Medicine, 1991; 388). Animals in each group began to be administered 1 week before the experiment. The mice in the high-dose group were administrated with 20% Baodandan 0.5ml/ton; the low-dose group was treated with 10% Baozhandan 0.5ml/only. The stomach; The control group was intragastrically administered with the same dose of distilled water once daily for 1 week, 30 min after the last administration, with 20% carbamide.