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谷胱甘肽是哺乳动物细胞内主要的非蛋白硫基,在细胞解毒过程中起着重要作用.它以还原型(GSH)和氧化型(GSSH)两种形式平衡存在.体外和体内研究表明,总谷胱甘肽浓度与化疗抗药性及放疗耐受性呈正相关,应用消耗谷胱甘肽的药物(如BSO和马来酸乙二酯,能消除获得性抗药性.然而迄今为止尚未对肿瘤GSH状态及其与疗效的关系进行研究,因大多数肿瘤需经某种创伤性手术取样,并且活检标本中细胞成份量不同(即基质或肿瘤细胞亚群GSH含量各异)可混淆谷胱甘肽测定.研究表明,甲状腺功能减退、核黄素缺乏症等
Glutathione is a major non-protein sulfur group in mammalian cells and plays an important role in cell detoxification. It exists in both reduced (GSH) and oxidative (GSSH) forms. In vitro and in vivo studies have shown that The total glutathione concentration was positively correlated with chemotherapy resistance and radiotherapy tolerance. The use of glutathione-consuming drugs (such as BSO and ethylene maleate) could eliminate acquired resistance. However, it has not been The relationship between tumor GSH status and its efficacy has been studied because most tumors undergo some kind of traumatic surgery and the amount of cellular components in biopsy specimens is different (ie, the content of GSH in the matrix or tumor cell subpopulation varies). Glycogenin determination. Studies have shown hypothyroidism, riboflavin deficiency, etc.