RAP1 is a well-known telomere-binding protein,but its functions in human stem cells have remained unclear.Here we generated RAP1-deficient human embryonic stem
Human embryonic stem cells (hESCs) depend on glycolysis for energy and substrates for biosynthesis.To understand the mechanisms goveing the metabolism of hESCs,
Many viruses,enveloped or non-enveloped,remodel host membrane structures for their replication,assembly and escape from host cells.Herpesviruses are important h
Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencaphalopathy (CADASIL) is a rare hereditary cerabrovascular disease caused by a NO
Detection of moving objects is an essential skill for animals to hunt prey,recognize conspecifics and avoid predators.The zebrafish,as a vertebrate model,primar
Mitochondrial dysfunctions play major roles in ageing.How mitochondrial stresses invoke downstream responses and how specificity of the signaling is achieved,ho
Primitive mammalian heart transforms from a single tuba to a four-chambared muscular organ during a short developmental window.We found that knocking out global
N6-methyladenosine (m6A),a ubiquitous RNA modification,is installed by METTL3-METTL14 complex.The structure of the heterodimeric complex between the methyltrans