磷酯酶D(PLD)作为一种磷酯酶,不仅能催化甘油磷酯末端的磷酸二酯键水解,而且在合适醇类受体存在的情况下,PLD还可以催化转磷酯酰基反应,将磷酯酰基转移到醇类上,生成相应的磷酯衍生物。但不同来源的PLD其转酰基活性的潜能不同,这主要与PLD的HKD模序及环形区域结构相关。本文就PLD的结构与其活性的关系予以简要综述。 Phospholipase D (PLD), as a phospholipase, not only catalyses the hydrolysis of the phosphodiester bond at the end of glycerophosphate, but also catalyzes the transphosphonothioyl reaction in the presence of a suitable alcohol receptor, Phosphatidyl transfers to alcohols to form the corresponding phospholipid derivative. However, PLDs of different origins have different potentials of transacylation activity, which is mainly related to the structure of the HKD motif and the circular region of PLD. This article briefly reviews the relationship between the structure and activity of PLD.