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目的:分析研究冠心病伴有结直肠癌对血脂水平造成的影响,以及对其采取调脂治疗的临床治疗效果。方法:抽取2011年4月-2013年8月在我院收治的患有冠心病伴有结直肠癌的病人40例(实验组),同时抽取血脂检查TC全部都在5.70mmol/L或者在5.70mmol/L以上的冠心病病人40例(对照组),对两组病人均采取调脂治疗。结果:实验组TC以及LDL-C明显低于对照组,其差异具有统计学意义(P<0.05),实验组Lp(a)明显高于对照组,其差异具有统计学意义(P<0.05)。调脂治疗六个月以后,实验组的LDL-C和HDL-C水平持续下降,TC以及Lp(a)没有明显变化,其差异不具有统计学意义(P>0.05)。结论:结直肠癌病人的Lp(a)水平增高也许和结直肠癌抗肿瘤效应有密切关系,伴有冠心病的结直肠癌病人血脂谱变化在这种疾病病人当中采取调脂治疗的安全有效性提出更高的要求。
Objective: To analyze the effect of coronary heart disease associated with colorectal cancer on blood lipid levels, as well as the clinical treatment of lipid-lowering therapy. Methods: Forty patients (experimental group) with coronary heart disease and colorectal cancer who were admitted to our hospital from April 2011 to August 2013 were enrolled. At the same time, all the TCs of blood lipids were taken at 5.70mmol / L or at 5.70 40 cases of coronary heart disease patients with mmol / L or more (control group), both groups of patients taking lipid-lowering treatment. Results: The levels of TC and LDL-C in the experimental group were significantly lower than those in the control group (P <0.05). The Lp (a) in the experimental group was significantly higher than that in the control group (P <0.05) . After six months of lipid-lowering therapy, LDL-C and HDL-C levels in the experimental group continued to decline, TC and Lp (a) did not change significantly, the difference was not statistically significant (P> 0.05). Conclusion: The increased Lp (a) levels in patients with colorectal cancer may be closely related to the antitumor effect of colorectal cancer. The changes of blood lipid profile in patients with colorectal cancer with coronary heart disease are safe and effective in taking lipid-lowering therapy in patients with this disease Sex put forward higher requirements.