论文部分内容阅读
1926年Banting与Gairns发现双侧肾上腺切除的实验动物的血清钠浓度增高,钾浓度下降;从而得知肾上腺是参与调节体内电解质平衡的重要器官之一。但当时,他们并不知道是肾上腺里的什么物质在起作用。1953年Simpson与Tait报告了他们从皮质醇中成功地分离出一种“钠储留因子”。以后,他们又接着研究这种物质的化学结构,发现该“因子”原来是天然存在的,具有生物活性并有一个醛基的类固醇。因而命名为“醛固酮”。现在,我们都知道醛固酮是体内盐皮质激素的主要代表;它以调节钠、钾通过细胞膜的速率来影响体内电解质的平衡。醛固酮促进肾脏远端肾小管对钠的再吸收与钾、氢离子的排出。
Banting and Gairns in 1926 found that bilateral adrenalectomy in experimental animals increased serum sodium concentration, decreased potassium concentration; adrenal gland that is involved in the regulation of electrolyte balance in the body of one of the important organs. At the time, however, they did not know what the substance in the adrenal glands was at work. In 1953 Simpson and Tait reported that they successfully isolated a “sodium storage factor” from cortisol. Later, they went on to study the chemical structure of this substance and found that the “factor” was originally a naturally occurring, biologically active steroid with an aldehyde group. It is therefore named “Aldosterone.” Now, we all know that aldosterone is the main representative of mineralocorticoids in the body; it affects the balance of electrolytes in the body by regulating the rate at which sodium and potassium pass through the cell membrane. Aldosterone promotes the sodium reabsorption of renal proximal tubules and the release of potassium and hydrogen ions.