论文部分内容阅读
新型降压药物多沙唑嗪(doxazosin)是一种和哌唑嗪结构相近的选择性α_1-肾上腺素受体阻滞剂,具有抗高血压和降低血胆固醇(Ch)的双重作用。1 药理作用 ①α_1-受体阻滞作用:这一作用与哌唑嗪相同,但选择性强于哌唑嗪。其对动静脉均有扩张作用,使收缩压、舒张压、平均动脉压均有降低,外周血管阻力减少,且有扩冠状动脉作用。②抗血小板聚集:体内外实验均已证实本药对ADP、胶原、肾上腺素诱导的血小板聚集有明显的拮抗作用,且呈剂量依
Doxazosin, a new antihypertensive drug, is a selective α 1 -adrenoceptor blocker with prazosin structure and has the dual effects of antihypertensive and hypocholesterolemic (Ch) lowering. 1 Pharmacological effects ① α_1-receptor block: This effect is the same as prazosin, but the selectivity is stronger than prazosin. Its expansion of the role of arteriovenous, systolic blood pressure, diastolic blood pressure, mean arterial pressure were reduced, peripheral vascular resistance decreased, and coronary artery expansion. ② anti-platelet aggregation: in vitro and in vivo experiments have confirmed that the drug on ADP, collagen, epinephrine-induced platelet aggregation was significantly antagonistic and dose dependent