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目的探讨鸦胆子油乳经血管介入治疗原发性肝癌的临床效果、对患者免疫水平及预后的影响。方法选取2011年1月-2016年3月在我院实施介入手术治疗的原发性肝癌患者100例,采用SPSS 16.0生成随机数字表分为治疗组、对照组各50例,治疗组采用鸦胆子油乳+常规化疗栓塞,对照组仅采用常规化疗栓塞治疗。对比两组患者的临床疗效。结果治疗后,治疗组患者的肿瘤病灶较对照组缩小更加明显(P<0.05);且治疗组的总有效率84.00%高于对照组的72.00%,但差异无统计学意义(P>0.05),治疗组的NK、CD3+、CD4+、CD4+/CD8+的水平高于对照组,差异均具有统计学意义(P<0.05);治疗组的2年生存率26.00%与对照组的16.00%比较差异无统计学意义(P>0.05);治疗组的中位生存时间17.0个月高于对照组的12.5个月(P<0.05)。结论鸦胆子油乳经血管介入治疗原发性肝癌有利于改善患者的免疫学水平、对患者的远期预后有利。
Objective To investigate the clinical effect of transcatheter injection of Brucea javanica oil on the patients with primary hepatocellular carcinoma (HCC) and its effect on the immune status and prognosis of patients. Methods From January 2011 to March 2016 in our hospital 100 cases of primary liver cancer interventional surgery, the use of SPSS 16.0 random number table is divided into treatment group and control group of 50 cases, the treatment group with Brucea javanica Oil emulsion + conventional chemoembolization, the control group only with conventional chemotherapy embolization. Compare the clinical efficacy of two groups of patients. Results After treatment, the tumor lesions in treatment group were more obvious than those in control group (P <0.05). The total effective rate in treatment group was 84.00%, which was higher than that in control group (72.00%), but the difference was not statistically significant (P> 0.05) . The levels of NK, CD3 +, CD4 +, CD4 + / CD8 + in the treatment group were higher than those in the control group (P <0.05). The 2-year survival rate was 26.00% in the treatment group and 16.00% in the control group. (P> 0.05). The median survival time of the treatment group was 17.0 months higher than that of the control group 12.5 months (P <0.05). Conclusion Brucea javanica oil transvascular interventional treatment of primary liver cancer is conducive to improve the patient’s immunological level, the long-term prognosis of patients favorable.