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To investigate the distribution of variant genotypes of Fc gamma receptor Ⅲ a (FcγR Ⅲ a)in healthy Chinese population of Zhengzhou city, genomic DNA was extracted from peripheral bloodof healthy donators. The genotypes of FcγR Ⅲ a-158 were determined by nested polymerase chainreaction (PCR) in 137 healthy people in Zhengzhou city. The results showed that frequencies of va-riant genotypes FF, VV and VF were 42.3 %, 48.9 % and 8.8 % respectively. The distributionof FcγR Ⅲ a-158 in healthy Chinese population of Zhengzhou city was polymorphic and differentfrom that of African Americans (AA) and Caucasian Americans (CA).