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平行测定了138例肝病患者血清中Ⅱ型前胶原、Ⅳ型胶原、透明质酸、层粘连蛋白、脯氨酸肽酶5项指标水平,并与51名正常者对照。结果显示:慢性活动性肝炎、肝硬化组各项指标均明显升高（均P<0.01）,而慢性迁延性肝炎组各项指标仅轻度升高,与正常对照组比较无显著差别（均P>O.05）。五项指标联检发现慢性活动性肝炎组、肝硬化组分别有64.1％、85.6％患者出现三项指标以上阳性,而正常对照组五项指标全阴者占92.1％。提示多项指标联检可提高诊断肝纤维化的准确性。
The serum levels of type Ⅱ procollagen, type Ⅳ collagen, hyaluronic acid, laminin and proline peptidase were measured in parallel in 138 patients with liver disease and compared with 51 normal controls. The results showed that all indexes of chronic active hepatitis and cirrhosis group were significantly increased (all P <0.01), while those of chronic persistent hepatitis group only increased slightly, which were not significantly different from those of normal control group P> O.05). Five indicators of joint detection found that chronic active hepatitis group, liver cirrhosis group were 64.1%, 85.6% of patients showed more than three indicators positive, while the normal control group of five indicators of all yin accounted for 92.1%. Prompted a number of indicators joint examination can improve the accuracy of diagnosis of liver fibrosis.