目的：了解淋球菌流行株对抗生素的耐药性。方法：对１９９８ ～１９９９ 年间广东省湛江地区分离出的９８ 株淋球菌流行株，在系统鉴定的基础上，进行了抗生素敏感性的测定，分别用纸片扩散法和琼脂稀释法测定青霉素、四环素、壮观霉素、头孢三嗪和环丙沙星的抑菌圈直径（ ｍ ｍ ） 和最小抑菌浓度（ ＭＩＣ） ，根据ＮＣＣＬＳ 标准判定药物敏感性。结果：纸片扩散法测定淋球菌对这５ 种抗生素的耐药百分率分别为３２－６５ ％ 、６９－３９ ％ 、８－１６ ％ 、１３－２７ ％ 和８２－６５ ％ ，而琼脂稀释法测得相应的耐药 百分 率为 ２３－９１ ％ 、４９－４６ ％ 、１１－１１ ％ 、１６－４８ ％ 和５９－３４ ％ 。结论：湛江地区目前流行的淋球菌菌株耐药状况十分严重，尤以环丙沙星为甚，临床常用的头孢三嗪、壮观霉素耐药株也应引起重视 Objective: To understand the resistance of gonococcal strains to antibiotics. Methods: 98 strains of Neisseria gonorrhoeae isolated from Zhanjiang, Guangdong Province from 1998 to 1999 were tested for antibiotic susceptibility based on systematic identification. The antibacterial activity of penicillin, tetracycline , Spectinomycin, ceftriaxone and ciprofloxacin inhibition zone diameter (m m) and minimum inhibitory concentration (MIC), according to the NCCLS criteria to determine the drug sensitivity. Results: The percentage of drug resistance of Neisseria gonorrhoeae to these five antibiotics was 32-65%, 69-39%, 8-16%, 13-27% and 82-65% respectively by disk diffusion method, while the agar dilution method The corresponding percentages of resistance were 23-91%, 49-46%, 11-11%, 16-48% and 59-34%. Conclusion: The current prevalence of Neisseria gonorrhoeae strains in Zhanjiang is very serious, especially ciprofloxacin, ceftriaxone and spectinomycin resistant strains commonly used clinically