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目的:观察射频热疗联合胸腔灌注华蟾素、顺铂对乳腺癌所致恶性胸腔积液患者的临床疗效和不良反应。方法:62例确诊为乳腺癌伴恶性胸腔积液患者随机分为两组,热疗组32例患者采用射频热疗联合华蟾素与顺铂胸腔灌注治疗,对照组30例患者仅采取华蟾素与顺铂胸腔灌注治疗,治疗进行一月后对两组患者进行近期疗效率及Kamofsky(KPS)评分对比研究。结果:热疗组近期疗效总有效率为87.5%,优于对照组的66.7%;热疗组KPS提高率(93.8%)明显高于对照组(70.0%),差异均具有统计学意义(P<0.05)。两组不良反应发生率差异无统计学意义。结论:射频热疗联合胸腔灌注顺铂和华蟾素明显提高了乳腺癌致恶性胸腔积液的治疗效果,患者的生存质量得到明显改善,是一种具有临床应用价值的治疗方法。
Objective: To observe the clinical effects and adverse reactions of radiofrequency thermotherapy combined with pleural perfusion of cinobufacini and cisplatin on patients with malignant pleural effusion caused by breast cancer. Methods: Sixty-two patients with breast cancer with malignant pleural effusion were randomly divided into two groups. Thirty-two patients in the hyperthermia group were treated with radiofrequency thermotherapy combined with cinobufacini and cisplatin. Thirty patients in the control group received only Chinese toad Supramolecular and cisplatin pleural perfusion therapy, treatment for one month after the two groups of patients with short-term efficacy and Kamofsky (KPS) score comparison study. Results: The total effective rate was 87.5% in the hyperthermia group and 66.7% in the control group. The increase rate of KPS in the hyperthermia group (93.8%) was significantly higher than that in the control group (70.0%), the difference was statistically significant (P <0.05). There was no significant difference in the incidence of adverse reactions between the two groups. Conclusion: Radiofrequency thermotherapy combined with pleural perfusion of cisplatin and cinobufacin significantly improves the therapeutic efficacy of malignant pleural effusion in patients with breast cancer. The quality of life of patients has been significantly improved, which is a clinically valuable therapeutic method.