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腹膜透析是终末期肾病的一种有效的替代治疗。腹膜透析中多种因素可引起腹膜上皮细胞-间充质转变(EMT)和腹膜炎症,进而导致腹膜结构和功能的改变,最终引起腹膜纤维化。研究表明多种分子机制参与腹膜纤维化过程,其中转化生长因子-β(TGF-β)发挥着重要的作用,TGF-β可以通过Smad依赖和Smad非依赖通路参与多种促纤维化事件,其中包括EMT。本文将针对近年来一些关于腹膜纤维化进展的分子机制进行总结。
Peritoneal dialysis is an effective alternative to end-stage renal disease. Various factors in peritoneal dialysis can cause peritoneal epithelial cell-mesenchymal transition (EMT) and peritoneal inflammation, leading to changes in peritoneal structure and function, eventually leading to peritoneal fibrosis. Studies have shown that a variety of molecular mechanisms involved in peritoneal fibrosis process, including transforming growth factor-β (TGF-β) plays an important role, TGF-β through Smad-dependent and Smad-independent pathways involved in a variety of fibrosis events, including Including EMT. In this paper, we will summarize some molecular mechanisms in recent years about the progress of peritoneal fibrosis.