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目的 :评价加替沙星的体外抗菌作用。方法 :以琼脂稀释法测定加替沙星对临床分离菌的最低抑菌浓度 (MIC) ,并与有关抗菌药进行比较。测定加替沙星的杀菌作用 ,以及各种培养条件对加替沙星抗菌活性的影响。结果 :加替沙星对临床分离菌 1192株MIC测定结果显示该药具广谱抗菌作用。对甲氧西林敏感金黄色葡萄球菌 (MSSA)、肺炎链球菌、溶血性链球菌、流感嗜血杆菌具高度抗菌活性 ,MIC90 ≤ 0 .2 5mg/L。但对甲氧西林耐药葡萄球菌 (MRS)和肠球菌属的作用差。对肠杆菌科细菌的大多数菌株具良好抗菌作用 ,其中对肺炎克雷伯菌、沙雷菌属、普通变形杆菌、沙门菌属、志贺菌属的MIC90 ≤ 2mg/L。但大肠埃希菌的敏感性较差。该药对铜绿假单胞菌、嗜麦芽窄食单胞菌亦具良好抗菌作用 ,不动杆菌属对其敏感性较差。加替沙星对脆弱拟杆菌、消化链球菌等厌氧菌亦具高度抗菌活性。与受试的其他氟喹诺酮类药物相比 ,加替沙星对MSSA、肺炎链球菌、溶血性链球菌、脆弱拟杆菌的作用明显优于环丙沙星和氧氟沙星 ,对肠杆菌科细菌和非发酵革兰阴性菌作用较环丙沙星略优或相仿。杀菌试验结果显示加替沙星具快速杀菌作用。除培养基的pH值改变对其抗菌活性略有影响外 ,细菌接种量及血清含量无明显影响。结论 :加替沙星为一广谱抗菌药
Objective: To evaluate the in vitro antibacterial effect of gatifloxacin. Methods: The minimum inhibitory concentration (MIC) of gatifloxacin on clinical isolates was determined by agar dilution method and compared with the antibacterials. The antibacterial effect of gatifloxacin and the effect of various culture conditions on the antibacterial activity of gatifloxacin were determined. Results: Gatifloxacin clinical isolates of 1192 MIC determination results show that the drug has a broad-spectrum antibacterial effect. Methicillin-sensitive Staphylococcus aureus (MSSA), Streptococcus pneumoniae, hemolytic streptococcus, Haemophilus influenzae with a high degree of antibacterial activity, MIC90 ≤ 0.25mg / L. However, methicillin-resistant Staphylococcus aureus (MRS) and Enterococcus genus poor. The majority of Enterobacteriaceae strains with good antibacterial effect, which against Klebsiella pneumoniae, Serratia, Proteus vulgaris, Salmonella, Shigella MIC90 ≤ 2mg / L. However, the sensitivity of Escherichia coli is poor. The drug on Pseudomonas aeruginosa, Stenotrophomonas maltophilia also has good antibacterial activity, Acinetobacter is less sensitive to them. Gatifloxacin against Bacteroides fragilis, Peptostreptococcus and other anaerobic bacteria also have a high degree of antibacterial activity. Compared with other fluoroquinolones tested, the effect of gatifloxacin on MSSA, Streptococcus pneumoniae, hemolytic streptococcus and Bacteroides fragilis was significantly better than that of ciprofloxacin and ofloxacin. Bacteria and non-fermented gram-negative bacteria act slightly better than or similar to ciprofloxacin. Bactericidal test results showed that gatifloxacin with rapid bactericidal effect. In addition to the change of the pH of the medium slightly affected its antibacterial activity, the inoculum size and serum content had no significant effect. Conclusion: Gatifloxacin is a broad-spectrum antimicrobial agent