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目的：通过检测碱性成纤维细胞生长因子Ｂａｓｉｃｆｉｂｒｏｂｌａｓｔｇｒｏｗｔｈｆａｃｔｏｒ，ｂＦＧＦ）与Ⅳ型胶原（ＩＶｔｙｐｅｃｏｌａｇｅｎ，ＩＶ－ｃｏｌ）、层粘连蛋白（Ｌａｍｉｎｉｎ，ＬＮ）在婴幼儿血管瘤中的表达，探讨它们与血管瘤发病机理的关系。方法：采用ＳＰ免疫组化法和图像分析技术，对７０例婴幼儿血管瘤组织中的ｂＦＧＦ、ＩＶ－ｃｏｌ和ＬＮ进行了定性和定量分析。结果：ｂＦＧＦ位于胞浆，胞核染色较淡；但主要位于细胞外基质，呈线网状分布。ＩＶ－ｃｏｌ，ＬＮ主要位于小血管及增生的腺管周围，连续线状分布。三者在血管瘤组织中均呈高表达，且ｂＦＧＦ与ＩＶ－ｃｏｌ、ＬＮ之间相关关系显著。结论：ｂＦＧＦ和细胞外基质的高表达与血管瘤的发生、发展密切相关。
OBJECTIVE: To detect the expression of basic fibroblast growth factor (bFGF) and IVtypecolagen (IV-col) and laminin (LN) in infantile hemangiomas and to explore their relationship with the incidence of hemangiomas Mechanism of the relationship. Methods: The bFGF, IV-col and LN in 70 infantile hemangiomas were qualitatively and quantitatively analyzed by SP immunohistochemistry and image analysis. Results: bFGF was located in the cytoplasm, staining of the nucleus was light, but mainly located in the extracellular matrix with a reticular distribution. IV-col, LN mainly located in the small blood vessels and hyperplastic duct around the continuous linear distribution. All three showed high expression in hemangiomas, and the correlation between bFGF and IV-col and LN was significant. Conclusion: The high expression of bFGF and extracellular matrix is closely related to the occurrence and development of hemangiomas.