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为了探讨一氧化氮对妊娠高血压综合征（妊高征）胎盘微循环的调节作用，利用彩色多普勒超声测定妊高征患者（妊高征组）及正常晚孕妇（对照组）子宫动脉及脐动脉最大收缩期与舒张末期血流速度之比，即Ｓ／Ｄ值，并观察了部分病例胎盘绒毛血管的超微结构改变，并测定了胎盘组织一氧化氮合酶（ＮＯＳ）活性。结果显示，中、重度妊高征患者的胎盘绒毛血管有不同程度的改变，妊高征组胎盘组织ＮＯＳ活性与脐动脉Ｓ／Ｄ值呈负相关（Ｐ＜０．０５）。结果提示，妊高征组胎盘微循环的异常改变可能与胎盘组织ＮＯＳ活性降低有关。
To investigate the role of nitric oxide in the regulation of placental microcirculation in pregnancy induced hypertension syndrome (PIH), uterine arteries were measured by color Doppler ultrasonography in patients with PIH and normal late pregnant women (control group) And the ratio of maximal systolic to end-diastolic blood flow velocity (S / D) of umbilical artery. The ultrastructural changes of placental villi in some cases were observed and the activity of nitric oxide synthase (NOS) in placenta was measured. The results showed that placental villi vessels in patients with moderate and severe pregnancy-induced hypertension had varying degrees of change. NOS activity in placenta of PIH was negatively correlated with S / D of umbilical artery (P <0.05). The results suggest that abnormal changes of placental microcirculation in pregnancy induced hypertension may be related to the decrease of NOS activity in placenta.