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目的:调查新兵亚临床结核感染与OT试验强阳性的相关性,探讨军队结核病预防新措施。方法:采用ELISA和免疫层析法分别检测了10399名新兵中OT强阳性者血清抗38KDa抗体和抗LAM(脂阿拉伯甘露聚糖)抗体;对抗体阳性者作为期3个月随访和1年信访。结果:OT强阳性新兵血清抗LAM抗体均为阴性;无卡痕和有卡痕OT强阳性组血清抗38KDa抗体阳性分别有5例和1例,阳性比率分别为3.96%和0.56%,差异显著(P<0.05)。抗体阳性者3个月随访发现:无卡痕OT强阳性组有3例新兵出现结核体质特征或症状,其中2例1年内诊断为胸膜炎结核,1例因身体不适调离原工作岗位。结论:血清抗38KDa抗体水平与新兵结核菌亚临床感染有关。OT强阳性且38KDa抗体阳性新兵,应给于3个月预防性抗痨治疗。
OBJECTIVE: To investigate the correlation between recruit TB sub-clinical TB infection and OT test strongly positive and to explore new measures for preventing tuberculosis in PLA army. Methods: Serum anti-38KDa antibody and anti-LAM antibody against 10AM recruits were tested by ELISA and immunochromatography. The antibody-positive patients were followed up for 3 months and 1-year post-mortem . Results: Serum anti-LAM antibodies of OT-positive recruits were all negative. There were 5 cases and 1 case of anti-38KDa antibodies positive in card-free and card-smear positive OT groups, the positive rates were 3.96% and 0.56%, respectively, with significant difference (P <0.05). Antibody positive 3 months follow-up found: no card marks OT positive group of 3 recruits appeared tuberculosis physical characteristics or symptoms, of which 2 cases within 1 year diagnosed as pleurisy tuberculosis, 1 case of physical discomfort transferred from the original job. Conclusion: The level of serum anti-38KDa antibodies is related to subclinical TB infection among recruits. OT-positive and 38KDa antibody-positive recruits should be given 3 months of preventive anti-tuberculosis treatment.