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目的通过对62名静脉吸毒艾滋病病人的高效抗逆转录病毒治疗(HAART)队列为期1年的观察,了解在治疗不同时间队列的变化情况、免疫学和病毒学指标的变化趋势及治疗效果。方法2006年6月20日-2007年1月25日期间,纳入了62名初次参加HAART的静脉吸毒艾滋病人,分别在其治疗前、治疗1、6和12个月进行问卷调查和实验室检测。结果在12个月的随访过程中,共有24人(38.7%)因各种原因退出治疗队列。在坚持治疗的患者中,免疫学成功的患者在治疗不同时间CD4+T淋巴细胞增长在统计学上有明显差异,治疗失败者只在治疗12个月有增长。与基线相比治疗不同时间的病毒载量呈现不断下降趋势,治疗6个月和12个月,分别下降了2.51g拷贝/ml和2.61g拷贝/ml。结论吸毒人群抗病毒治疗随访队列的终止治疗率较高,抗病毒治疗的免疫学疗效较差,患者自报的服药依从性与疗效不符,结果有偏移。
Objective To investigate the changes of cohorts, immunological and virological trends and the therapeutic effects in 62 cohorts of highly active antiretroviral therapy (HAART) cohorts of intravenous drug users for one year. Methods Between June 20, 2006 and January 25, 2007, 62 HIV-infected patients who initially participated in HAART were enrolled and questionnaires and laboratory tests were conducted before treatment, 1, 6 and 12 months after treatment . Results During the 12-month follow-up, a total of 24 (38.7%) patients dropped out of the cohort for various reasons. Among adherence-treated patients, there was a statistically significant difference in CD4 + T-lymphocyte growth between immunocompromised patients at different times of treatment, with treatment losers increasing only after 12 months of treatment. The viral load at different times of treatment showed a decreasing trend compared with the baseline. After 6 months and 12 months of treatment, the viral load decreased by 2.51g copies / ml and 2.61g copies / ml respectively. Conclusions The termination rate of ART cohorts in follow-up cohorts of drug addicts is high, and the immunological efficacy of anti-virus treatment is poor. Patients’ self-reported medication compliance and curative effect are inconsistent and the results are offset.