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目的综合分析抗线粒体抗体-M2型(AMA-M2)阳性就诊人群实验室血常规、生物化学等检测指标,使得原发性胆汁性肝硬化(PBC)早发现、早确诊、早防治。方法收集2010年1月-2015年12月本院就诊AMA-M2阳性患者669例,健康体检者600例,分别比较分析血常规异常、生化指标异常的情况。结果 AMA-M2阳性669例患者中血常规异常420例,异常比为62.78%(420/669),对照组血常规异常105例,异常比为17.50%(105/600),2组差异有统计学意义(χ~2=267.38,P<0.05)。AMA-M2阳性669例患者中生化指标异常总例数382例,异常比为57.10%(382/669),对照组生化指标异常78例,异常比为13.00%(78/600),2组差异有统计学意义(χ~2=266.20,P<0.05)。结论对于实验室检测血常规及肝功能等指标异常患者,应及早进行AMA-M2等自身抗体的检测,以利于PBC的早期确诊,降低误诊漏诊率,提高患者生活质量。
OBJECTIVE: To comprehensively analyze the laboratory blood routine and biochemical indexes of anti-mitochondrial antibody-M2 (AMA-M2) -positive patients, so that primary biliary cirrhosis (PBC) can be detected early, diagnosed early and prevented early. Methods A total of 669 AMA-M2 positive patients and 600 healthy volunteers were collected in our hospital from January 2010 to December 2015. The abnormalities of blood and biochemical indexes were compared and analyzed respectively. Results Among the 669 AMA-M2-positive patients, there were 420 abnormal blood tests, the abnormal ratio was 62.78% (420/669), the control group had 105 abnormal blood tests, the abnormal ratio was 17.50% (105/600) Significance (χ ~ 2 = 267.38, P <0.05). The total number of biochemical abnormalities in AMA-M2 positive patients was 382, with an abnormality ratio of 57.10% (382/669). There were 78 biochemical abnormalities in the control group with an abnormality ratio of 13.00% (78/600) There was statistical significance (χ ~ 2 = 266.20, P <0.05). Conclusion For patients with laboratory abnormalities such as blood tests and liver function tests, autoantibodies such as AMA-M2 should be detected early in order to facilitate the early diagnosis of PBC, reduce the misdiagnosis rate and improve the quality of life of patients.