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24例符合研究诊断标准(RDC)的病人,男女各12例,均为重性抑郁症患者;此外对22例(男8,女14)正常对照者,均测定了尿游离皮质酸及尿MHPG(3-甲氧4-羟苯乙二醇)。方法:住院的24例重性抑郁病人,在服抗抑郁药至少一周前留24小时尿标本作游离皮质醇和MHPG测定,尿液先用四氯化碳处理以减少尿中影响试验结果的类固醇和皮质酮以及17-羟皮质醇,然后用氯钾烷提出尿中的皮质醇,经过真空干燥后再溶于有缓冲液试管中进行放射免疫测定。结果显示抑郁症组的尿游离皮质醇(195±24μg/24 小时)
Twenty-four patients (RDC) had 12 men and women, all of whom were patients with major depressive disorder. In addition, urine free cortisol and urine MHPG were measured in 22 normal controls (male 8 and female 14) (3-methoxy 4-hydroxyphenylglycol). METHODS: Twenty-four major depressive patients in hospital were enrolled in a 24-hour urine sample taken at least one week prior to antidepressants as free cortisol and MHPG determination. Urine was first treated with carbon tetrachloride to reduce the effects of steroids and Corticosterone and 17-hydroxycortisol, and then urinary cortisol was raised with chlorotoluene, dried in vacuo and then dissolved in a buffer tube for radioimmunoassay. The results showed that urinary free cortisol in depression group (195 ± 24 μg / 24 hours)