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目的 :为观察中药葛根素与地尔硫及 SOD对心肌缺血再灌注损害的保护作用。方法 :将 45只小型猪造成在体心肌缺血再灌注模型 ,分为 5组 ,分别于再灌注前经静脉注射生理盐水、 SOD、地尔硫 (DTZ) ,DTZ+SOD和葛根素。结果 :1心梗范围占左室质量的百分数 ,用药各组与对照组比较 ,均有显著性缩小 ,P <0 .0 1;DTZ+SOD组与 SOD组比较 ,亦有显著缩小 ,P<0 .0 5 ;2心肌钙离子含量 :SOD组与对照组比较有降低 ,但无显著性差异 ,而 DTZ组、SOD+DTZ组及葛根素组与对照组比较均有显著性的降低 ,P <0 .0 1;3用药组均有降低灌注后 CK- MB的作用。 DTZ组、 SOD+DTZ组及葛根素组灌注后的 CK- MB与对照组比较均有显著性差异 ,P <0 .0 1,与 SOD组比较 ,DTZ组、SOD+DTZ组及葛根素组均有显著性降低 ,P <0 .0 1。结论 :SOD、 DTZ、葛根素对缺血再灌注心肌有明确的保护作用 ,但 DTZ、葛根素效果优于 SOD,葛根素的效果与 DTZ近似 ,合用 SOD+DTZ较应用其中单一药物效果更好。
Objective : To observe the protective effects of puerarin, diltiazem and SOD on myocardial ischemia-reperfusion injury. METHODS: Forty-five minipigs were established in a model of myocardial ischemia and reperfusion in vivo. Five groups were divided into five groups: saline, SOD, diltiazem (DTZ), DTZ+SOD and puerarin were injected intravenously before reperfusion. RESULTS: 1The percentage of myocardial infarction was the percentage of left ventricular mass. Compared with the control group, each group had a significant decrease, P<0.01. The DTZ+SOD group had a significant decrease compared with SOD group, P< 0. 05;2 Cardiac Calcium Ion Content: Compared with the control group, the SOD group had a decrease, but there was no significant difference, but the DTZ group, SOD+DTZ group and puerarin group had a significant decrease compared with the control group. <0. 0 1; 3 medication groups have reduced the role of CK-MB after perfusion. The CK-MB after perfusion in DTZ group, SOD+DTZ group, and puerarin group were significantly different from the control group (P < 0.01), compared with SOD group, DTZ group, SOD+DTZ group and puerarin group. Significantly decreased, P < 0.01. Conclusion: SOD, DTZ, and puerarin have clear protective effects on ischemia-reperfusion myocardium, but DTZ and puerarin are better than SOD. The effect of puerarin is similar to that of DTZ. The combination of SOD and DTZ is more effective than the single drug. .